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offprint Dec 24, 2006 2. Zitvogel L, et al. Cancer in spite of immunosurveillance. Immunosubversion and immunosuppression Nat. Rev. Immunol. 2006 Oct 6, 715–27. 3. Casares N, et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med. 2005 Dec 19;202(12):1691–701. IWR1 4. Apetoh L, et al. TLR4 -dependent contribution of the Milciclib solubility dmso Immune system to the antitumor effects of chemotherapy and radiotherapy. Nat. Med. Aug; 2007. O142 Inflammation and Cancer: Insights into Organ-specific Immune Regulation of Cancer Development Lisa M. Coussens 1 1 Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA The concept that leukocytes are components of malignant tumors is not new; however, their functional involvement as promoting forces for tumor progression has only recently been appreciated. We are interested in understanding the molecular mechanisms that regulate leukocyte recruitment into neoplastic tissue and subsequent regulation those leukocytes exert on evolving cancer cells. By studying transgenic mouse models of skin, lung and breast cancer development, we have recently appreciated that adaptive leukocytes differentially regulate myeloid cell recruitment, activation, and behavior, by organ-dependent mechanisms.

Thus, whereas Pifithrin-�� supplier chronic inflammation of premalignant skin neoplasms is B cell–dependent, during mammary carcinogenesis, T cells appear to play more of a dominant role in regulating pro-tumor and pro-metastatic properties of myeloid cells. To be presented will be recent insights into organ and tissue-specific regulation of epithelial cancer development by adaptive and innate immune cells, and thoughts on how these properties

can be harnessed for effective anticancer therapeutics. Funding from the National Institutes of Health and a Department of Defense Era of Hope Scholar Award. O143 Intratumoral Immune Reaction: A Novel Paradigm for Cancer Jerome Galon 1 1 Integrative Cancer Immunology, Dapagliflozin INSERM U872, Paris, France To date the anatomic extent of tumor (TNM classifications) has been by far the most important factors to predict the prognosis of colorectal cancer patients. However, the impact of immune responses and tumor escape on patient prognosis in human cancer is poorly understood. We showed that tumors from human colorectal cancer with a high density of infiltrating memory and effector memory T-cells (TEM) are less likely to disseminate to lymphovascular and perineural structures and to regional lymph-nodes. We showed that the combination of immune parameters associating the nature, the density, the functional orientation and the location of immune cells within the tumor was essential to accurately define the impact of the local host immune reaction on patients prognosis.