Conclusions Ischemic conditioning seems to prevent HIF-1α mRNA in

Conclusions Ischemic conditioning seems to prevent HIF-1α mRNA induction in the rat liver after ischemia and reperfusion. This suggests that the protective effects of ischemic

conditioning do not involve the HIF-1 system. On the other hand, the magnitude of the HIF-1α response might be a marker for the degree of I/R injuries after liver ischemia. APR-246 Further studies need to be performed to elucidate this matter. Acknowledgements The excellent technical assistance by Karen Mathiassen and Kirsten Nyborg is highly appreciated. The work was supported by the Health Research Fund of Central Denmark Region, Danish Medical Research Council, the Eva and Henry Frænkels Memorial Foundation and the Clinical Institute, University of Aarhus, Denmark. References 1. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH: Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. AnnSurg 1999, 230:309–318. 2. Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, Hess K, Curley SA: Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. AnnSurg 2004, CP673451 solubility dmso 239:818–825. 3. Pawlik TM, Scoggins CR, Zorzi D, Abdalla EK, Andres A, Eng C, Curley SA, Loyer

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