Results. No differences Panobinostat in vivo in patients and graft survival at 5 years were identified for patients with a low MELD score between recipients of LDLT ( 81.7 and 78.2%) compared to recipients of DDLT stratified

by low DRI risk (80.7 and 78%), moderate risk (80.5 and 74.1%) and high risk DRI (68.9 and 56.4%) (p= 0.2 and 0.053 ) respectively. Similarly, patients with a low MELD Score have similar rates of ACR . In contrast, for high MELD Score patients and graft survival at 5 years were statistically significantly lower for those that received DDLT and a DRI score of >2 (64.1 and 52%), when compared to a low DRI score (82.5 and 79% ), moderate DRI scores (60 and 56%) and LDLT ( 78 and 74%)(p= 0.04 and 0.01) respectively . The incidence of ACR for the group with a High MELD score was equivalent in all groups . Complications rate were greater in living donors with High and Low MELD Score mostly related to biliary stricture and sepsis. Conclusions. Matching DRI and MELD scores provide a meaningful tool to predict patient and graft survival . High MELD Score patient benefit from receiving organs with low DRI or living donors. This findings allows to stratified donor -recipient pairs and facilitate counseling patients and their potential donors in regards to clinical outcome

when live donor liver is an option for transplantation. Disclosures: The following people have nothing to disclose: Yucel Yankol, Luis A. Fernandez, Turan Kanmaz, Glen E. Leverson, David Foley, Bayindir Cimsit,

Joshua D. Mezrich, Nesimi Mecit, Janet M. Bellingham, Anthony M D’Alassendro, Koray Acarli, Munci Kalayoglu INTRODUCTION: Selumetinib supplier Roux-en-Y medchemexpress choledochojejunostomy and duct-to-duct anastomosis are two potential methods for biliary reconstruction in liver transplant (LT) for recipients with Primary Sclerosing Cholangitis (PSC). However, there is controversy over which method of biliary reconstruction yields superior clinical outcomes. It has been previously reported that Roux-en-Y loop reconstruction may reduce the incidence of postoperative stricture formation, and improve patient and graft survival when compared with duct-to-duct anastomosis in LT. For this reason, Roux-en Y choledochojejunostomy is historically the default biliary reconstruction technique in the transplant of a PSC recipient. However, some publications have suggested that duct-to-duct anastomosis may be preferable in well-selected patients with native duct preservation as it more effectively restores the normal anatomy and function of the biliary tree, facilitates postoperative access of the biliary tree, and is associated with less operative time and shorter postoperative recovery time. The purpose of this study was to evaluate the clinical outcomes of duct-to-duct biliary anastomosis versus Roux-en-Y choledochojejunostomy in patients undergoing LT for PSC.