(C) 2010 Elsevier Inc. All

rights reserved.”
“Objective: To study the effect of different mail- and phone-based strategies, along with patient- and research-related factors, on the time to contact with research participants.

Study Design and Setting: A prospective evaluation of a 12-week standardized protocol (embedded with two randomized trials of mail- and phone-based Histone Methyltransf inhibitor strategies) for contacting existing research participants for recruitment into a related study.

Results: Of 146 participants, 87 were eligible for contact via the standardized protocol, and 63 (72%) of these were successfully contacted within 12 weeks after multiple mail- and phone-based efforts. Using Cox proportional hazards regression analysis, the different mail and phone strategies showed no significant difference in the time to contact with participants. Of 34 patient- and research-related factors evaluated, only two were independently associated with time to contact among all 146 participants: (1) participants having their last visit conducted outside of the research

clinic because of patient illness/condition had a longer time to contact and (2) those with a self-reported chronic fatigue history had a shorter time to contact.

Conclusion: Few patient characteristics and research-related factors accurately predict time Selleckchem INCB028050 to contact. Repeated attempts using different strategies are important for successful and timely contact with study participants. (C) 2011 Elsevier Inc. All rights reserved.”
“Objective: To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB) and hippocampal volume (HV) as predictors of conversion from mild cognitive impairment

(MCI) to dementia. Methods: Twenty-eight individuals (9 normal and 19 with MCI) were classified according to their CDR sum of boxes scores into 3 groups. Results: The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. Conclusion: We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient GSK621 cell line as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.”
“Objective: To develop a simple clinical screening tool for community-dwelling older adults.

Study Design and Setting: A prospective multicenter cohort study was performed among healthy subjects of 65 years and older, examined in 10 health examination centers for the French health insurance. Falls were ascertained monthly by telephone for 12-month follow-up. Multivariate analyses using Cox regression models were performed. Regression coefficients of the predictors in the final model were added up to obtain the total score.