Compared with non-users, those who became snus users experienced higher prevalence of relaxation and pleasurable buzz (all p < .001 for both men and women). Men who became snus users experienced higher prevalence of dizziness (p = .004), whereas women who became snus users experienced lower prevalence of dizziness (p = .031) Dorsomorphin BMP compared with non-users of the same sex. Compared with non-users, women who became snus users also experienced higher prevalence of pleasant sensations (p < .001) and lower prevalence of unpleasant sensations (p = .014) and nausea (p = .021). Table 3. Initial Reactions to Snus by Type of User and Sex for 1,383 Participants From STAGE Who Experimented With Only Snus (ES) Results of analyses using the Chi-square test to compare across the four categories of EC+S (��non-user of both,�� ��exclusive smoker,�� ��exclusive snus user,�� and ��dual user��) indicate the prevalence of every initial reaction differed by type of user (all p < .

001) (data not shown). For men and women, future use of either tobacco product was associated with a favorable initial reaction to that product. Those who became exclusive smokers experienced higher prevalence of favorable reactions to cigarettes, but not snus, and vice versa. Those who became regular dual users experienced higher prevalence of pleasant sensations, relaxation, pleasurable buzz and dizziness, and lower prevalence of unpleasant sensations and nausea, in response to both cigarettes and snus. Positive reactions (including pleasant sensations, relaxation, and pleasurable buzz) were more common among ES than EC, occurring among 40%�C57% of ES men and women and only 31%�C36% of EC men and women.

Dizziness was experienced by a majority of participants, with 59% of EC men and 69% of EC women and 87% of ES men and 71% of ES women experiencing at least mild dizziness. Among men, ES experienced significantly more dizziness (p < .001) and nausea (p < .001) than EC. Finally, ES experienced significantly more unpleasant sensations than EC (male p = .032, female p < .001). Binary Recursive Partitioning Results Figure 1 presents classification trees for initial reactions to cigarettes predictive of becoming a smoker among EC. Despite the significant association between several initial reactions and regular smoking in univariate analysis, BRP identified only buzz as predictive of being a smoker among men.

Men were predicted to be smokers with a probability of .63 if they experienced any buzz when they first tried cigarettes. BRP identified two reactions as predictive of being a smoker among women, dizziness and difficulty inhaling. Women were predicted to be smokers with a probability of .60 if they experienced any dizziness and no difficulty inhaling when they first tried cigarettes. Women who experienced no dizziness at Dacomitinib first use had a predicted probability of only .28 for being a smoker. Figure 1 .