Cravings decreased significantly from base line for sweets, fast foods, fats, and carbohydrates by 2 weeks and remained significantly reduced in both arms throughout the 12 weeks of study. There were no statisti cal differences between the arms from 2 weeks through 12 weeks. Also, hunger satiety did not differ at baseline between the arms. Hunger between selleck products the three major meals, and general hunger throughout the day decreased from baseline to 8 and 12 weeks in subjects on both arms. However, hunger between the end of the evening meal and retiring decreased Inhibitors,Modulators,Libraries significantly only in the PED arm at both 8 and 12 weeks, but not in the MED arm. No differences between the arms were noted in quality of life questionnaire form Medical Outcome Study Short Form 36.

Weight loss, waist circumference, Inhibitors,Modulators,Libraries and BP Although this was not designed to be a weight loss study, subjects in both arms who completed the 12 week study lost nearly identical amounts of weight. Similarly, in both groups, waist circumference was reduced significantly at 8 and 12 weeks. With regard to BP, subjects in the PED arm experienced reductions in both systolic and diastolic Inhibitors,Modulators,Libraries BP at the end of the trial. from 129. 7 3. 5 mm Hg at base line to 123. 4 2. 7 mm Hg at 12 weeks for systolic BP, and from 87. 0 2. 3 mm Hg at baseline to 82. 0 2. 0 mm Hg at 12 weeks for diastolic BP. Sub jects in the MED arm, on the other hand, displayed a decline only in systolic BP, their diasto lic BP remained unchanged throughout the study. Serum lipids and apolipoproteins Effects of intervention diets on cardiometabolic risk vari ables are summarized in Table 3 and individual responses are illustrated in Fig.

3. Subjects in both arms experienced reductions in total cholesterol, LDL, non HDL choles terol, and cholesterol HDL at 8 weeks and 12 weeks of the trial. The decrease Inhibitors,Modulators,Libraries in total cholesterol and non HDL cho lesterol from baseline to 12 weeks was greater in the PED than in the MED arm the average percent reduction in total cholesterol was 14. 5% in the PED Inhibitors,Modulators,Libraries arm but only 6. 3% in the MED arm and in non HDL cholesterol was 18. 2% in the PED arm but only 8. 0% in the MED arm. The decrease in cholesterol HDL was greater in the PED than in the MED arm. With regard to serum TG and TG HDL, a recognized marker of MetS, subjects in both arms experienced reduc tions at 8 weeks.

However, only subjects in the PED arm continued to exhibit decreases in serum TG and TG HDL at 12 weeks. the difference between the 2 arms was signif icant at 12 weeks. There was an average selleck kinase inhibitor 42. 7% reduction in TG HDL in the PED arm and only a 17. 6% decrease in the MED arm. Serum HDL increased from baseline to 12 weeks only in subjects on the PED arm, and remained unchanged in the MED arm. Compared to baseline, the total LDL parti cle number decreased in the PED arm at 8 and 12 weeks, and in the MED arm only at 12 weeks. VLDL particle number decreased at both 8 and 12 weeks only in the PED arm.