Haberle conocido y haber compartido tantos momentos con él siempre nos permitirá decir en momentos de duda: ¿qué hubiera hecho Miguel? Seguro que de su recuerdo encontraremos muchas soluciones. Su mujer Loli, su hermano José Luis y sus hijas han perdido un ser muy querido, pero todos los que le hemos tenido como un referente humano y profesional también hemos quedado de alguna manera un poco huérfanos. Hasta siempre Miguel Junta Directiva de la Asociación Española de Gastroenterología Patronato de la Fundación Española de Gastroenterología “
“Reactive oxygen/nitrogen species (ROS) such as superoxide anion, hydrogen peroxide and hydroxyl radical

are known to induce damage of key biological components and cell membranes (Halliwell see more and Gutteridge, 2007). In order to counteract the deleterious effects of reactive species, cells developed a specialized machinery of antioxidant defence (Mugesh and Singh, 2000). Cellular defence against ROS requires the expression of antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase which play central role in the detoxification of reactive species (Finkel and Holbrook, 2000 and Arteel and Sies, 2001). Methylmercury (MeHg) Linsitinib manufacturer has been recognized as a ubiquitous environmental toxicant

whose toxicity is associated to neurological and developmental deficits in animals and humans (Clarkson et al., 2003). Although environmental hazards such those occurred in the past in Japan and Iraq between the 50s and 70s, several anthropogenic sources DAPT concentration of MeHg still pose high risk to human and environmental health (Hylander and Goodsite, 2006). Also important, it has been shown that mercury transport from more densely populated regions (lower latitudes) results in the accumulation of methylmercury in the food chain of Arctic and Antarctic environments (Barkay and Poulain, 2007). Due to its potential bioaccumulation in fish, as well as its intensive

applications in industry, coal fired power plants and mining, intoxication episodes are mainly related to diet and occupational exposures (Clarkson et al., 2003, Hylander and Goodsite, 2006 and Honda et al., 2006). The central nervous system (CNS) is highly susceptible to MeHg toxic effects and the developing brain has been shown to be largely sensitive to the neurotoxic actions of this organometal (Johansson et al., 2007 and Grandjean and Herz, 2011). The exact mechanisms underlying MeHg toxicity are not fully understood. However, it has been shown that oxidative stress plays a central role in this process (Aschner et al., 2007 and Farina et al., 2011a). MeHg-induced oxidative stress seems to be related to direct oxidative properties of MeHg toward endogenous thiol and selenol groups in low molecular weight molecules as well as proteins (Shanker et al., 2005 and Farina et al., 2011b).