In this scenario laparoscopic surgery

has become a valid option as diagnostic and therapeutic means. In some referral centres delayed laparoscopy is even routinely proposed [8]. Thus laparoscopy should not be considered as a failure of NOM but as a part of this therapeutic strategy. In our experience laparoscopy was performed because of appearance of an inflammatory response on blood test and diffused peritonitis at clinical examination. Finally, utilisation of hemostatic and tissue sealing agent (Nycomed TachoSil®) seams to give an effective control of biliary fistula. In our case the biliary leakage was successfully treated by application of the surgical patch on the liver fracture after scrupulous lavage of the hepatic surface. Utilisation of such a device in elective liver surgery is well known and its hemostatic properties are already reported [9]. Afterwards, tissue sealing characteristics were observed in repairing AZD0156 manufacturer air leakage following pulmonary resection [10]. Moreover, bile leaks reduction after application of Tachosil surgical patch, was observed in a retrospective series about adult split liver transplantation

[11] and resective hepatic surgery [12]. Probably, a real tissue repairing and LY2835219 reinforcing properties with construction of a neo hepatic glissonien capsule could be supposed. In our experience the patient did Copanlisib molecular weight not develop any biliary fistula documented by drainage output and any endoscopic complementary procedure was necessary to treat the biliary injury. In conclusion laparoscopy and application of Tachosil surgical patch was an efficient and definitive treatment of a biliary complication following NOM of blunt liver injury. Consent Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review

by the Editor-in-Chief of this journal Electronic supplementary material Additional file 1: Video of surgical procedure Biliary peritonitis following blunt liver trauma. (M4V 19 MB) References 1. Richardson JD: Changes in the management of injuries to the Thiamine-diphosphate kinase liver and spleen. J Am Coll Surg 2005,200(5):648–69.CrossRefPubMed 2. Christmas AB, Wilson AK, Manning B, Franklin GA, Miller FB, Richardson JD, Rodriguez JL: Selective management of blunt hepatic injuries including nonoperative management is a safe and effective strategy. Surgery 2005,138(4):606–10.CrossRefPubMed 3. Velmahos GC, Toutouzas K, Radin R, Chan L, Rhee P, Tillou A, Demetriades D: High success with nonoperative management of blunt hepatic trauma: the liver is a sturdy organ. Arch Surg 2003,138(5):475–80.CrossRefPubMed 4. Carrillo EH, Reed DN Jr, Gordon L, Spain DA, Richardson JD: Delayed laparoscopy facilitates the management of biliary peritonitis in patients with complex liver injuries. Surg Endosc 2001,15(3):319–22.CrossRefPubMed 5.