Science 2000, 299: 1753–1755.CrossRef 21. Hassan Baf-A1 nmr AB, Howell JA: Insulin-like growth factor 2 supply modifies growth of intestinal adenoma in Apc(Min/+) mice. Cancer Res 2000, 60: 1070–1076.PubMed 22. Cui H, Horon IL, Ohlsson R, Hamilton SR, Feinberg AP: Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite
instability. Nat Med 1998, 4: 1276–1280.CrossRefPubMed 23. Lee MP, DeBaun MR, Mitsuya K, Galonek HL, Brandenburg S, Oshimura M, Feinberg AP: Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor 2 imprinting. Proc Natl Acad Sci USA 1999, 96: 5203–5208.CrossRefPubMed 24. Mitsuya K, Meguro M, Lee MP, Katoh M, Schulz TC, Kugoh H, Yoshida MA, Niikawa N, Feinberg AP, Oshimura M: LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids. Hum Mol Genet 1999, 8: 1209–1217.CrossRefPubMed 25. Tanaka K, Shiota G, Meguro M, Mitsuya K, Oshimura M, Kawasaki H: Loss of imprinting of long QT intronic transcript 1 in colorectal cancer. Oncology
2001, 60: 268–273.CrossRefPubMed 26. Nakano S, selleck products Murakami K, Meguro M, Soejima H, Higashimoto K, Urano T, Kugoh H, Mukai T, Ikeguchi M, Oshimura M: Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers. Cancer Sci 2006, 97: 1147–1154.CrossRefPubMed 27. Soejima H, Nakagawachi T, Zhao W, Higashimoto K, Urano T, Matsukura S, Kitajima Y, Takeuchi M, Nakayama M, Oshimura M, Miyazaki K, Joh K, Mukai T: Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer. Oncogene 2004, 23: 4380–4388.CrossRefPubMed 28. Wu MS, Wang HP, Lin CC, Sheu JC, Shun CT, Lee WJ, Lin JT: Loss of imprinting and overexpression
of IGF2 gene in gastric adenocarcinoma. Cancer Lett 1997, 120: 9–14.CrossRefPubMed 29. Cruz-Correa M, Cui H, Giardiello FM, Powe NR, Hylind L, Robinson A, Hutcheon DF, Kafonek DR, Brandenburg S, Wu Y, He X, Feinberg AP: Loss of imprinting Thiamet G of insulin growth factor 2 gene: a potential heritable biomarker for colon neoplasia predisposition. Gastroenterology 2004, 126: 964–970.CrossRefPubMed 30. Sakatani T, Wei M, Katoh M, Okita C, Wada D, Mitsuya K, Meguro M, Ikeguchi M, Ito H, Tycko B, Oshimura M: Epigenetic heterogeneity at imprinted loci in normal populations. Biochem Biophys. Res Commun 2001, 283: 1124–1130. 31. check details Ulaner GA, Yang Y, Hu JF, Li T, Vu TH, Hoffman AR: CTCF binding at the insulin-like growth factor-2 (IGF2)/H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues. Endocrinology 2003, 144: 4420–4426.CrossRefPubMed 32.