The main result was that activation in the right selleck products substantia nigra was significantly correlated

with fatigue (P = 0.02). There was also a marginally significant correlation between fatigue and activation in the left PPC (P = 0.08). When extracting the eigenvariate measures of the BOLD responses from the correlated activation peaks in these two ROIs we found significantly correlated activation in both regions. In the substantia nigra the correlation coefficient, r, was 0.69 and the P-value for the linear regression was less than 0.001. For Inhibitors,research,lifescience,medical the PPC the corresponding statistics were r = 0.77 and P < 0.001. Controlling for working memory performance and reaction time during the fMRI task did not significantly change these results. The localizations of voxels in the right substantia nigra and the left PPC that were significantly or marginally significantly correlated to fatigue VAS scores and the corresponding regression graphs are shown in Figure Inhibitors,research,lifescience,medical ​Figure5.5. Both graphs show a positive correlation, which means that participants

with higher ratings of perceived fatigue have higher activation in the right substantia nigra and the left PPC during Inhibitors,research,lifescience,medical performance of the working memory task. Note that the brain responses in Figure ​Figure55 are centered round zero, and thus the signs of the responses have no quantitative values. None of the predefined ROIs were negatively correlated to fatigue. Figure 5 Brain Inhibitors,research,lifescience,medical activation with positive correlation to perceived fatigue during the working memory task. The images show positively correlated voxels in regions of interest: the right substantia nigra and the left posterior parietal

cortex (PPC). The image of … Functional connectivity The overview analysis of connections between nodes in the thalamo-striato-cortical network resulted in a schematic model (Fig. ​(Fig.6)6) that broadly resembles the theoretical model described by Alexander and Crutcher (1990) (Fig. ​(Fig.1).1). The main difference was that, due to the low anatomical detail in the predefined ROIs, Inhibitors,research,lifescience,medical we were not able to differentiate between the globus pallidus externa and interna and between the substantia nigra pars compacta and pars reticulata. Another important difference between our schematic model and the theoretical model was that we did not model the subthalamic Cilengitide nucleus, as this region was not activated by the working memory task. Figure ​Figure66 shows how the cortical regions (DLPFC and PPC) were connected to each other and to the striatum. The substantia nigra was coupled to both the striatum and to the thalamus. Note that in the theoretical model, the pars compacta of the substantia nigra is coupled to the striatum, whereas the pars reticulata is coupled to the thalamus. In our schematic model, the thalamus was also coupled to the cortex and the basal ganglia, as described in the theoretical model.