The prostate cancer detection rates (CDRs) of 6-, 8-, 10- and 12PBx were compared for each individual subgroup. Results: The 12PBx detected 253 (27.4%) cases of prostate cancer (PCa), of which 67.2, 47.1 and 61.3% were located in the base, mid-gland and apex, respectively. Multivariate analysis indicated that age, TRUS status and PV were independent risk factors for PCa detection. CDR increased with increasing biopsy cores. However, for patients with age Selleckchem BKM120 >= 65 years, positive TRUS and PV <38.5 cm(3), CDR of 8PBx (30.6%)

was similar to 10PBx (32.2%) and 12PBx (32.2%); for patients with age >= 65 years, negative TRUS and PV <38.5 cm(3) or ones with age >= 65 years, positive TRUS and PV >= 38.5 Autophagy inhibitor libraries cm(3), 10PBx was as effective as 12PBx in detecting PCa (27.8, 27.5 vs. 28.9, 29.3%, respectively). Conclusion: Age, TRUS status and PV were independent risk factors for PCa detection. Traditional sextant biopsy is not recommended. 8-, 10-, or 12PBx as an individual biopsy scheme might be adopted according to these risk factors for Chinese patients. Copyright (c) 2012 S. Karger AG, Basel”
“For the prototypical SiGe/Si(001) Stranski-Krastanow (SK) growth system, the influence of intermixing caused by the deposition of a Si cap layer at temperatures T(cap) between 300 degrees C and 700 degrees C is studied both for the SiGe wetting

layer (WL) and the SiGe islands. Systematic growth experiments were carried out with an ultrahigh resolution of down to 0.005 monolayers (ML) of deposited Ge. The properties of the samples were investigated via photoluminescence (PL) spectroscopy, atomic force microscopy selleck kinase inhibitor (AFM), and transmission electron microscopy. We studied in detail the influence of T(cap) in the three main coverage regions of SiGe SK growth, which are (i) the WL build-up regime, (ii) the island

nucleation regime, where most of the Ge is supplied via material transfer from the WL, and (iii) the saturation regime, where the WL thickness remains initially stable. At T(cap) = 300 degrees C, we found that both the WL and the island are essentially preserved in composition and shape, whereas at 500 degrees C the WL becomes heavily alloyed during capping, and at 700 degrees C the islands also become alloyed. At T(cap) = 500 degrees C we found enhanced WL intermixing in the presence of dome-shaped islands, whereas at T(cap) = 700 degrees C the WL properties become dominated by the dissolution of pyramid-shaped islands upon capping. At Ge coverages above approximate to 6 ML, we found an unexpected thickening of the WL, almost independently of T(cap). This finding suggests that the density and the volume of the dome-shaped islands have an upper limit, beyond which excess Ge from the external source again becomes incorporated into the WL.