Glycogen was examined both in the liver and skeletal selleck inhibitor muscles of control and extract treated diabetic rats, whereas, the activity of glycolytic enzyme glucokinase and gluconeogenic enzyme glucose-6-phosphatase was examined in the liver. Oral administration of aqueous extract of C. ternatea leaves (400 mg/kg body weight) and flowers (400 mg/kg body
weight) for 84 days significantly reduced serum glucose, glycosylated hemoglobin, total cholesterol, triglycerides, urea, creatinine and the activity of gluconeogenic enzyme glucose-6-phosphatase, but increased serum insulin, HDL-cholesterol, protein, liver and skeletal muscle glycogen content and the activity of glycolytic enzyme glucokinase. For all the above biochemical parameters investigated, C. ternatea leaves treated rat showed a little better activity than C. ternatea flowers treated diabetic rats. The present investigation suggests that
C. ternatea leaves and flowers extract exhibit antihyperglycaemic and antihyperlipidaemic effects and consequently may alleviate liver and renal damage associated with alloxan-induced diabetes mellitus in rats.”
“The aim of this study was to evaluate neurological manifestations of primary Sjogren’s syndrome (pSS) and investigate the etiology and pathogenesis of peripheral and central nervous complications Compound C in pSS. Thirty-two patients with pSS were enrolled in the present study, 20 of whom had neurological involvement plus sicca symptoms. The clinical features were evaluated by neurological examinations including nerve conduction study,
magnetic resonance imaging, cerebrospinal fluid, and electroencephalogram. The frequency of fever was significantly higher (P = 0.006) in pSS with neurological involvement than in pSS without neurological involvement. There was no statistical significance in other factors between the two groups. Peripheral nervous system (PNS), central nervous system (CNS), and both PNS and CNS involvements were revealed in 14, 3, and 3 patients, respectively. Optic neuritis and trigeminal neuralgia were revealed frequently in cranial neuropathy. Anti-aquaporin 4 antibody was detected in one patient with optic BMS-777607 research buy neuritis. Of the nine patients with polyneuropathy, eight patients presented pure sensory neuropathy including small fiber neuropathy (SFN). pSS with SFN appeared to have no clinically abnormal features, including muscle weakness and decreasing deep tendon reflex. Skin biopsy revealed epidermal nerve fiber degenerated in one pSS patient with pure sensory neuropathy who was diagnosed as having SFN. Our observations suggest that a number of mechanisms can be attributed to neurological involvements in pSS rather than just the mechanisms previously described (i.e., vasculitis and ganglioneuronitis). Presumably, specific autoantibodies may directly induce injury of the nervous system.”
“Lung cancer classification is of paramount importance in determining the treatment for oncologic patients.