Methods: This was a single-center case series of adult lymphoma patients at high risk of TLS who received a single fixed dose of rasburicase. Patients had to have their uric acid, serum creatinine,
lactate dehydrogenase and electrolytes monitored for at least 24-48 h post-administration.
Results: Eleven patients were identified. Majority were Chinese (91%), male (64%) and with a median age of 61 years (range 41-84). All had at least two risk factors for developing TLS. Ten patients received a 6-mg dose and one received 4.5 mg. Prior to rasburicase administration, the mean uric acid level was 835 mu mol/L (range 318-1237 mu mol/L) and the level 24-h post-administration was 186 mu mol/L (range 30-653 mu mol/L) (P < 0.001). Eight patients (73%) experienced an improvement find more of renal function 72-h post-rasburicase. Normalization of serum electrolytes Selleck AZD7762 was achieved within 96 h.
Conclusion: Among Asian lymphoma patients who manifested at least two risk factors for developing TLS, a single fixed dose of rasburicase at 6 mg is deemed to be effective for rapidly lowering uric acid levels as well as sustaining reduced levels for up to 72 h.”
“Doxorubicin is an effective agent for many malignancies. To limit cardiotoxicity, doxorubicin can be given
as prolonged infusion (PIDX) or bolus infusion following dexrazoxane (DZX). The authors report their institutional experience comparing PIDX and DZX STI571 nmr in a sarcoma cohort. Retrospective record review for newly diagnosed sarcoma patients at the University
of Texas M. D. Anderson Cancer Center from June 1998 to June 2006. There were 23 Ewing’s sarcoma (EWS) patients treated with DZX and 40 osteosarcoma (OS) patients treated with PIDX. The DZX group had higher mean cumulative anthracycline dose (510 mg/m(2) [SD 120 mg/m(2)] versus 414 mg/m(2) [SD 99 mg/m(2)], P = .002), however mean lowest left ventricular ejection fraction (EF) values were higher for DZX (52.5% [SD 5.6%] versus 47.2% [SD 10.9%], P = .014). Fifteen of 19 patients with cardiac dysfunction were PIDX patients (P = .15). Five PIDX patients required cardiac medication, and 1 patient died of congestive heart failure (CHF). Sixteen patients with cardiac dysfunction had improvement, demonstrated by EF >= 50% at last echocardiogram. Although not statistically significant, there were 4 DZX patients with cardiac dysfunction. Prospective studies are required to determine which strategy has long-term advantages and if certain patients are at increased risk for cardiac dysfunction.”
“Cross-plane thermal diffusivity of a GaAs/AlGaAs-based vertical cavity surface emitting laser (VCSEL) is measured under operating conditions and active heat sinking using a thermoreflectance technique. Perpendicular thermal diffusivity is determined from the measurements of phase difference between the heating source and the temperature as a function of temperature modulation frequency. The value of (1.22 +/- 0.