NAFLD was present in 59.6%, borderline NASH in 14.2% and definite NASH in 6.4%. Stage 1 fibrosis was present
in 15.6% and stage 2 in 2.8%; 1 subject had stage 3 and none had cirrhosis. Compared 3-MA clinical trial to subjects with Not-NAFLD and with NAFLDNot NASH, more subjects with borderline/definite NASH were male and had diabetes and hypertension. Serum ALT, AST, HOMa-IR, and triglyceride levels were also higher. Pre-operative weight loss >5% occurred in 11% of subjects but did not vary by disease grade. Conclusions: The presence of NASH in a multicenter cohort of severely obese adolescents undergoing WLS was associated with male gender and higher cardiometabolic risk. While NAFLD was common, prevalence of advanced fibrotic NASH was low. This may reflect younger age, demographic or referral patterns, or biological factors specific to severe obesity and merits further study. Characteristics and significant determinants of liver histology Not-NAFLD (n=57) NAFLD-Not NASH (n=55) Borderline/Definite NASH (n=29) NAS=NAFLD activity score Disclosures: Marc Michalsky – Grant/Research
Support: Allergan Health, Irvine CA Thomas H. Inge – Grant/Research Support: Ethicon The following people U0126 in vitro have nothing to disclose: Stavra A. Xanthakos, Tawny P. Wilson, David E. Kleiner, Todd M. Jenkins, Reena Mourya, Mary L. Brandt, Carroll M. Harmon, Michael A. Helmrath, Anita P. Courcoulas, Meg H. Zeller Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to metabolic syndrome and obesity which are associated with an increased risk of various malignancies. In this study, we investigated the association between NAFLD and prostate cancer biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: Consecutive prostate cancer patients who underwent RP between 2005 and 2008 at a single tertiary hospital in Korea were included in this study. The 上海皓元 presence of NAFLD, body mass index (BMI), pre-diagnostic prostate-specific antigen
(PSA), and histological findings including Gleason score were analyzed with regard to their associations with BCR. NAFLD was diagnosed based on clinical information and ultrasonography or unenhanced CT images. BCR-free survival rates were calculated using the Kaplan-Meier method. Results: A total of 222 patients were analyzed. During a median follow-up period of 54 (inter-quartile range, 44-65) months, 45 (20.3%) patients developed BCR. The presence of NAFLD was significantly associated to longer time-to-BCR (P=0.001 by log rank test), while BMI failed to show statistical significance (P=0.861). In multivariate analysis, the presence of NAFLD (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.11-0.61; P=0.002), pathological Gleason score (compared to <7, 7: HR, 2.92; 95% CI, 1.12-7.64; P=0.029, >7: HR, 6.64; 95% CI, 2.26-19.52; P=0.001), and positive surgical margin (HR, 2.17; 95% CI, 1.18-3.99; P=0.013) were independent predictive factors of BCR.