These findings suggest that the oscillatory mechanisms underlying attentional orienting to representations held in working memory are similar to those engaged when attention is oriented in the perceptual space. “
“The mammalian olfactory system has developed some functionality Veliparib datasheet by the time of birth. There is behavioral and limited electrophysiological evidence for prenatal olfaction in various mammalian species. However, there have been no reports, in any mammalian species, of recordings from prenatal olfactory sensory neurons (OSNs) that express a given odorant receptor (OR) gene. Here we have performed patch-clamp recordings from mouse OSNs that
express the OR gene S1 or MOR23, using the odorous ligands Copanlisib mouse 2-phenylethyl alcohol or lyral, respectively. We found that, out of a combined total of 20 OSNs from embryos of these two strains at embryonic day (E)16.5 or later, all responded to a cognate odorous ligand. By contrast, none of six OSNs responded to the ligand at E14.5 or E15.5. The kinetics of the odorant-evoked electrophysiological responses of prenatal OSNs are similar to those of postnatal OSNs. The S1 and MOR23 glomeruli in the olfactory bulb are formed postnatally, but the axon terminals of OSNs expressing these OR genes may be synaptically active in the olfactory bulb at embryonic stages. The upper limit of the
acquisition of odorant responsiveness for S1 and MOR23 OSNs at E16.5 is consistent with the developmental expression patterns of components of the olfactory signaling pathway. “
“Mirror neurons (MNs) of the monkey ventral premotor cortex (area F5) are a class of cells that match the visual descriptions of others’ actions with correspondent motor representations in the observer’s brain. Several human Nintedanib (BIBF 1120) studies suggest that one’s own motor representations activated during action observation play a role in directing proactive eye movements to the site of the upcoming hand–target interaction. However, there are no data on the possible relationship between gaze behaviour and MN activity. Here we addressed this issue by simultaneously
recording eye position and F5 MN activity in two macaques during free observation of a grasping action. More than half of the recorded neurons discharged stronger when the monkey looked at the action than when it did not look at it, but their firing rate was better predicted by ‘when’ rather than by ‘how long’ the monkey gazed at the location of the upcoming hand–target interaction. Interestingly, the onset of MN response was linked to the onset of the experimenter’s movement, thus making motor representations potentially exploitable to drive eye movements. Furthermore, MNs discharged stronger and earlier when the gaze was ‘proactive’ compared with ‘reactive’, indicating that gaze behaviour influences MN activity.