Data on cytogenetic response and survival were analyzed by use of erythropoietic-stimulating agent. RESULTS: A total of 608 patients were included, and 217 patients received erythropoietic-stimulating agents. There were 30 thrombotic episodes. Patients who received erythropoietic-stimulating agents had a higher rate of thrombosis (8.5% vs 2.6%, P=.0025). There was no difference in cytogenetic response rate and survival by use of erythropoietic-stimulating

agent. Development of grade 3-4 anemia occurred in 62 (10%) patients and was associated with significantly worse response and survival in patients in late chronic phase. By multivariate analysis, use of erythropoietic-stimulating P5091 agents was not a risk factor for event-free survival. CONCLUSIONS: In our cohort of chronic phase CML patients, use of erythropoietic-stimulating agents did not impact survival or cytogenetic response rate, but was associated with a higher thrombosis rate. Severe anemia is associated with worse survival and response. Cancer 2011;117:982-91. (C) 2010 American Cancer Society”
“Background & Aims: Infectious gastroenteritis (IGE) is known to exacerbate previously diagnosed inflammatory bowel disease (IBD). However, limited data are available describing a causal link between IGE Sapanisertib clinical trial and incident IBD. Methods: By using a medical encounter data repository of active

duty military personnel., a study was conducted to assess IBD risk in subjects with an antecedent case of IGE. Results: Between

1999 and 2006, there were 3019 incident IBD cases and 11,646 PD173074 in vivo matched controls who were evaluated in a conditional logistic regression model. To control for potential misclassification, IGE episodes within 6 months of IBD diagnosis were excluded as exposures. After adjusting for potential confounders, an episode of IGE increased the risk of IBD (odds ratio, 1.40; 95% confidence interval, 1.19-1.66). The risk was slightly higher for Crohn’s disease compared with ulcerative colitis. In addition, there was an approximate 5-fold increase in IBD risk for persons with a previous irritable bowel syndrome diagnosis. Conclusions: These data support theories that the initiation of IBD is a multifactorial process that might include the disruption of normal gut homeostatic mechanisms. Further studies are warranted to evaluate the pathogen-specific risks, identify susceptible populations, and better understand the pathophysiologic relationship between IGE and IBD.”
“Modulation of coagulation has been successfully applied to ischemic disorders of the central nervous system (CNS). Some components of the coagulation system have been identified in the CNS, yet with limited exception their functions have not been clearly defined. Little is known about how events within the cerebral tissues affect hemostasis.

The actual filtering error variances or their traces of each fuser are guaranteed to have a minimal upper bound for all the admissible uncertainties of noise variances. A Lyapunov equation approach is presented to prove the robustness of the robust Kalman filters. The

concept of robust accuracy is presented and the robust accuracy relations among the local and fused robust Kalman filters are proved. Specially, the corresponding steady-state robust local and fused Kalman filters are also presented for multisensor time-invariant systems, and the convergence in a realization of the local and fused time-varying and steady-state Kalman filters is proved by the dynamic error system analysis (DESA) method and dynamic variance error system analysis (DVESA) find more method. A simulation example ABT-263 in vitro is given to verify the robustness and robust accuracy relations. (C) 2013 Elsevier B.V. All rights reserved.”
“Interindividual variations in dose requirements of oral vitamin K antagonists (VKA) are attributed to several factors, including genetic variant alleles of vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9), but also interaction

with co-medications. In this context, proton pump inhibitor (PPI)-related alterations of VKA maintenance dose requirements have been published. The present investigation aimed to test for an interaction profile of oral VKA-therapy and PPIs in relation to the CYP2C9 genotype. Median weekly stable VKA dose requirements over 1year were recorded in 69 patients. Patients were genotyped for CYP2C9*2, CYP2C9*3, VKORC1c.-1639G bigger than A and VKORC1c.174-136C bigger than T and assessed for an association with PPI use and total VKA maintenance dose requirements. PPI users with CYP2C9 genetic variations required significantly lower weekly

VKA maintenance doses than those with the wild-type 3-MA cost genotype (t-test: P=002). In contrast, in subjects without PPI use, the CYP2C9 genotype had no significant influence on oral VKA dose requirements. Further, the combined CYP2C9/VKORC1 genotype was a significant predictor for VKA dose requirements [linear regression: estimate: -147, standard error: 058 (P=001)]. In conclusion, in carriers of CYP2C9 gene variations, the interference with the VKA metabolism is modified by PPI co-medication and the VCKORC1 genotype. Preceding knowledge of the genetic profile and the awareness for potentially occurring severe over-anticoagulation problems under PPI co-medication could contribute to a safer and personalized VKA pharmacotherapy.”
“PURPOSE.

e., greater activity during the resting state than during an attention-demanding cognitive task. The default system consists mainly of the medial cancer metabolism inhibitor prefrontal and medial parietal areas. It has been proposed that this default activity is concerned with internal thought processes. Here, I first describe activities observed in the human default

system measured by several methods, in relation task performance, development, aging and psychiatric disorder. I will then introduce recent nonhuman primate studies that indicate correlated low-frequency spontaneous brain activity within the default system, high metabolic levels in these medial brain areas during rest and task-induced suppression of neuronal activity in the medial parietal area. Furthermore, I will present our data in which we found selleckchem task-induced deactivation in the monkey default system, and will examine similarities and differences in default activity between the human and nonhuman primate. Finally. I will discuss the functional significance of the default system and consider the possibility of internal thought processes in the

monkey. (C) 2011 Elsevier B.V. All rights reserved.”
“BACKGROUND. Compartment-specific epithelial and stromal expression of the secreted glycoprotein Dickkopf-related protein (Dkk)-3 is altered in age-related proliferative disorders of the human prostate. This study aimed to determine the effect of Dkk-3 on prostate stromal remodeling that is stromal proliferation, fibroblast-to-myofibroblast differentiation and expression of angiogenic GNS-1480 mouse factors in vitro.\n\nMETHODS. Lentiviral-delivered overexpression and shRNA-mediated knockdown of DKK3 were applied to primary human prostatic stromal cells (PrSCs). Cellular proliferation was analyzed by BrdU incorporation ELISA. Expression of Dkk-3, apoptosis-related genes, cyclin-dependent kinase inhibitors and angiogenic factors were analyzed by qPCR, Western blot analysis or ELISA. Fibroblast-to-myofibroblast differentiation was monitored by smooth muscle cell actin and insulin-like growth factor binding protein

3 mRNA and protein levels. The relevance of Wnt/-catenin and PI3K/AKT signaling pathways was assessed by cytoplasmic/nuclear -catenin levels and phosphorylation of AKT.\n\nRESULTS. Knockdown of DKK3 significantly attenuated PrSC proliferation as well as fibroblast-to-myofibroblast differentiation and increased the expression of the vessel stabilizing factor angiopoietin-1. DKK3 knockdown did not affect subcellular localization or levels of -catenin but attenuated AKT phosphorylation in PrSCs. Consistently the PI3K/AKT inhibitor LY294002 mimicked the effects of DKK3 knockdown.\n\nCONCLUSIONS. Dkk-3 promotes fibroblast proliferation and myofibroblast differentiation and regulates expression of angiopoietin-1 in prostatic stroma potentially via enhancing PI3K/AKT signaling.

90; P-combined = 6.2 x 10(-34)), with an average risk allele frequency in controls of 0.54%. This variant is only very weakly correlated (r(2) <= 0.06) with previously reported risk variants at 8q24, and its association remains significant after adjustment for all known risk-associated variants. Carriers of rs188140481[A] were diagnosed with MK-1775 solubility dmso prostate cancer 1.26 years younger than non-carriers (P = 0.0059). We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe.”
“In most organisms, an

intrinsic circadian (similar to 24-h) time-keeping system drives rhythms of physiology and behavior.

Within cells that contain a circadian clock, specific transcriptional activators and repressors reciprocally regulate each other to generate a basic molecular oscillator. A mismatch of the period generated by this oscillator with the external environment creates circadian disruption, which can have adverse effects on neural function. Although several clock genes have been extensively characterized, PD-1/PD-L1 Inhibitor 3 solubility dmso a fundamental question remains: how do these genes work together to generate a similar to 24-h period? Period-altering mutations in clock genes can affect any of multiple regulated steps in the molecular oscillator. In this review, we examine the regulatory mechanisms that contribute to setting the pace of the circadian oscillator.”
“Cardanol-based, novolac-type phenolic resins were synthesized with a cardanol-to-formaldehyde molar ratio of 1 : 0.7 with different dicarboxylic acid catalysts, including oxalic and succinic acids. These novolac resins were epoxidized with a molar excess of epichlorohydrin at 120 degrees C in a basic medium. The epoxidized novolac resins were separately blended with different weight ratios of carboxyl-terminated butadiene-acrylonitrile copolymer (CTBN) ranging between 0 and 20 wt check details % with an interval of 5 wt %. All of the blends were

cured at 120 degrees C with a stoichiometric amount of polyamine. The formation of various products during the synthesis of the cardanol-based novolac resin and epoxidized novolac resin and the blending of the epoxidized novolac resin with CTBN was studied by Fourier transform infrared spectroscopy analysis. Furthermore, the products were also confirmed by proton nuclear magnetic resonance and matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy analysis. The molecular weights of the prepared novolacs and their epoxidized novolac resins were determined by gel permeation chromatography analysis. The blend samples, in both cases, with 15 wt % CTBN concentrations showed the minimum cure times. These blend samples were also the most thermally stable systems.

First, inverted lipid micelles in the bulk-oil phase gradually diffuse onto the oil/water interface. Next, the micelles are adsorbed on the interface and self-assemble to form the thread-like pattern. The essential characteristics of this pattern formation are theoretically reproduced by a simple Monte Carlo simulation that takes into account the kinetics in the coalescence of charged micelles on a 2D interface. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4722079]“
“Status epilepticus (SE) is a medical emergency. For diagnostic purposes

EEG is mandatory when motor phenomena are absent or when a single seizure evolves into SE with impaired consciousness. The EEG may show focal or generalized status patterns, which must be distinguished from encephalopathies. Initially benzodiazepines are recommended; Androgen Receptor screening lorazepam is the drug of choice. When the SE persists, phenytoin, valproate, levetiracetam, lacosamide, and phenobarbital

are administered. The choice depends on the underlying comorbidities. In this phase, only phenytoin is licensed. A generalized tonic-clonic status which is refractory is then treated with anesthetics including midazolam, disoprivan, or thiopental. The goal is to achieve burst suppression in the EEG and coadministration of antiepileptic drugs.”
“Nanocrystalline buy FK866 Dy doped BaMoO4 [Ba1-xDyxMoO4+x/2, where x=0, 0.05, 0.1, 0.15, and 0.2] samples were prepared by the acrylamide https://www.selleckchem.com/products/gm6001.html assisted sol-gel process. The prepared samples were characterized by TG/DTA, XRD,

FTIR, SEM-EDX and XRF techniques. From XRD patterns, crystalline phases for Ba1-xDyxMoO4+x/2, where x=0, 0.05, 0.1, 0.15, and 0.2 were confirmed and their average crystallite sizes calculated using Scherrer’s formula were found to be less than 80 nm. Thermal behavior and structure of Scheelite type nanocrystalline Ba1-xDyxMoO4+x/2, where x=0, 0.05, 0.1, 0.15, and 0.2 samples were identified using TG/DTA and FTIR measurements respectively. Microstructure and existence of O, Dy, Ba, and Mo in the Dy doped BaMoO4 samples were obtained from SEM-EDX and XRF results. The electrical conductivities of different compositions of the prepared nanocrystslline Dy doped BaMoO4 samples were evaluated by analyzing impedance data as a function temperature ranging from 350 to 650 degrees C under air using winfit software. Among the doped compositions, Ba0.90Dy0.10MoO4+delta exhibited high conductivity of 5.46 x 10(-3) S/cm at 650 degrees C. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.”
“Inflammatory response is a major defense mechanism against pathogens and chemical or mechanical injury. Rhus verniciflua Stokes (RVS) has traditionally been used as an ingredient in East Asian medicine for the treatment of gastritis, stomach cancer and atherosclerosis. The aim of the current study was to analyze the effect of RVS on LPS-induced inflammatory responses in the RAW264.7 mouse macrophage cell line. RAW264.

These studies were designed to determine the pharmacological relevance of the rabbit for the evaluation of potential effects on embryofetal development and to evaluate the placental transfer of intetumumab in rabbits. METHODS: In vitro pharmacology studies evaluated the binding of intetumumab to rabbit cells and the inhibition of vessel sprouting from rabbit aorta. For the evaluation of placental transfer, pregnant rabbits (8/group) were injected intravenously with intetumumab 50 or 100 mg/kg every 2 days from Gestation Day (GD)7 to GD19. Maternal sera, R788 fetal homogenates/sera, and amniotic

fluid were collected at necropsy on GD19 or GD28 for evaluation of intetumumab concentrations. Clinical condition of the dams was monitored and fetuses were screened for abnormalities. RESULTS: Intetumumab (5-40 mu g/mL) inhibited aortic cell adhesion to vitronectin and vessel sprouting from rabbit aortic rings. Immunohistochemical staining of rabbit tissues demonstrated binding of intetumumab to placenta. Administration of intetumumab to pregnant rabbits was well tolerated by the dams and the fetuses did not show major abnormalities. Fetal exposure to intetumumab relative

to maternal exposure was <0.1% on GD19 and 100-130% on GD29. CONCLUSIONS: The rabbit is a pharmacologically relevant species for evaluation of potential developmental effects of intetumumab. Intetumumab crosses the rabbit placenta during the fetal period (GD 19-28). Birth Defects Res (Part B) 89:116-123, 2010. (C) 2010 Wiley-Liss, Inc.”
“In Brazil, there appears to be no doubt concerning the selleck chemicals llc evils caused by Abraham Flexner, his Report, and the Flexnerian Biomedical Model (FBM), conceived and promoted by private foundations and linked to the U. S. health-industrial complex. In this article, I submit the above proposition to a rigorous critical inquiry. I begin with an overview of Flexner’s life and work. I then review various representations of the Flexnerian model

in the Brazilian literature Selleck Screening Library on health education, after which I identify inconsistencies, contradictions, and omissions by comparing the original Report to elements referring to the FBM. Finally, contrasting historical sources and imaginary representations, I analyze possibilities for interpreting the FBM as an intriguing and peculiar political mythology.”
“In order to ensure that the off-line arm of a two-arm-wheel combined inspection robot can reliably grasp the line in case of autonomous obstacle crossing, a control method is proposed for line grasping based on hand-eye visual servo. On the basis of the transmission line’s geometrical characteristics and the camera’s imaging principle, a line recognition and extraction method based on structure constraint is designed. The line’s intercept and inclination are defined in an imaging space to represent the robot’s change of pose and a law governing the pose decoupling servo control is developed.

The immunohistochemistry results showed that overexpression of EIF-5A2 was detected in none of normal epithelial mucosa, 35.3% of colorectal adenomas, 53.2% of primary colorectal carcinomas, and 67.6% of metastases. Amplification of eIF-5A2 was detected in 15.8% (16/101) of informative colorectal carcinomas, and most of them showed overexpression of

EIF-5A2. In primary colorectal carcinomas, the frequency of EIF-5A2 overexpression was significantly higher in colorectal carcinomas with lymphovascular invasion (61.2%) than that BYL719 nmr in colorectal carcinomas without lymphovascular invasion (36.6%, P <.05). In addition, significant positive associations were found between check details EIF-5A2 overexpression and the tumors’ later pN and pM stages, as well as increased tumor cell proliferation (P <.05). These findings suggest that overexpression of EIF-5A2 in colorectal carcinomas may be important in the acquisition of a metastatic phenotype and plays an important role in colorectal carcinoma development and progression. (c) 2008 Elsevier Inc. All rights reserved.”
“Background: Faecal incontinence affects a heterogeneous population and aetiology can be multifactorial. In a subset of patients the aetiology

retrains idiopathic despite standard investigations. Anal cushions are important in normal continence, but have rarely been studied. The aim of this study was to measure the size of the anal cushions and to evaluate their role in patients with idiopathic faecal

incontinence.\n\nMethods: Women in whom idiopathic faecal incontinence was diagnosed after standard anorectal investigations underwent transvaginal ultrasonography. The area of the anal cushions was measured and a cushion: canal (C: C) ratio derived, which was compared with that in a control selleck chemicals group of women without faecal incontinence.\n\nResults: Some 21 patients with incontinence (median age 60 gears) and 102 asymptomatic controls (median age 41 years) underwent scanning. The median (interquartile range) C: C ratio in the symptomatic group was significantly lower than that for controls (0.57 (0.54-0.66) versus 0.68 (0.61-0.73) respectively; P = 0.001). C:C ratio was not influenced by age (r = 0.023, P = 0821).\n\nConclusion: The C: C ratio was reduced in patients with idiopathic faecal incontinence.”
“Background: Although therapeutic angiogenesis is a most promising strategy for the treatment of myocardial infarction (MI), it remains unknown if and how endogenous angiogenesis inhibitors, such as endostatin, regulate angiogenesis in MI. In the present study the role of endostatin in left ventricular (LV) remodeling and heart failure was tested in a rat MI model.\n\nMethods and Results: When exposed to hypoxia, rat cardiomyocytes showed increased expression of endostatin.

Protocol subjects with hemoglobin (Hb) 100-129 g center dot L(-1) were given erythropoietin, dosed by weight. Subjects with Hb 130-139 g center dot L(-1) underwent preoperative autologous blood harvest and perioperative re-infusion as deemed clinically necessary. Subjects with Hb > 139 g center dot L(-1) received no special intervention, unless they were aged > 70 yr and weighed < 70 kg, in which case they received oral iron and folate supplementation.\n\nThe relative risk of ABT in the Study group

was 0.68 (95% confidence interval 0.54-0.85). signaling pathway The Control group received 104 units of allogeneic blood and the Study group received 35 units (P = 0.0007). These differences cannot be explained by differences in transfusion risk or autologous units transfused. There was no worsening of anemia or its consequences in the Study group.\n\nA simple protocol based on easily obtained preoperative clinical indices effectively targets interventions that mitigate the risk of ABT.”
“In neonates and children, sonographic examinations of the renal pyramids may depict a spectrum of unique changes Lonafarnib supplier in echogenicity due to the effects of physiologic processes or a wide variety of

pathologic processes that may affect the collecting ducts or interstitium of the pyramids. Focused sonographic evaluation of the pyramids with high-frequency transducers produces the most detailed images of the pyramids, revealing some appearances not previously reported, to the authors’ knowledge. The authors highlight the clinical settings in which they have documented detailed changes in the echogenicity of the pyramids. The patterns of altered echogenicity alone may reflect a specific cause but in many instances are nonspecific, with clinical and biochemical correlation required AZD6244 to establish a more precise diagnosis. However, there is a lack of histologic data to completely explain the mechanism of many of these

changes in echogenicity in all of the processes. As the authors have expanded their use of the focused sonographic technique, they have been able to depict altered echogenicity in the pyramids in greater numbers of children in whom an explanation for the changes is not always immediately apparent; for now, the cause must be considered idiopathic. More work is required to expand the use of this focused technique together with clinical, biochemical, and histologic correlation in an attempt to offer more complete explanations for the changes in echogenicity of the pyramids. (C) RSNA, 2010 . radiographics.rsna.org”
“Echocardiography has long been the mainstay of noninvasive cardiac diagnostic imaging; however, newer imaging modalities have proven useful in cases where echocardiography has been nondiagnostic.

2.\n\nResults This study of 4600 individuals identified four

single nucleotide polymorphisms with p<5×10(-8), the threshold set for genome-wide significance. We identified a variant in the PARK2 gene (p=2.8×10(-8)) associated with LDD. Differential methylation at one CpG island of the PARK2 promoter BMN 673 was observed in a small subset of subjects (beta=8.74×10(-4), p=0.006).\n\nConclusions LDD accounts for a considerable proportion of low back pain and the pathogenesis of LDD is poorly understood. This work provides evidence of association of the PARK2 gene and suggests that methylation of the PARK2 promoter may influence degeneration of the intervertebral disc. This gene has not previously been considered a candidate in LDD and further functional work is needed on this hitherto unsuspected pathway.”
“In continuation of our efforts to find a new class of antimicrobial agents, a series of 4-hetarylpyrazoles and furo[2,3-c]pyrazoles

were prepared via the reaction of 2-chloro-1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)ethanone ( 1) with an appropriate nucleophilic reagents. These compounds were screened for their antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Bacillus thuringiensis), Gram-negative bacteria (Escherichia coil and Pseudomonas aeruginosa) and antifungal activity against Fusarium oxysporum and Botrytis fabae. Among the synthesized compounds,

1-(5-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-yl)-2-methylfuran-3-yl)ethanone click here (12) showed equal selleck products activity with chloramphenicol against B. subtilis (MIC 3.125 mu g/mL), while its activity was 50% lower than of chloramphenicol against B. thuringiensis. N-[(4Z)-3-Methyl-1-phenyl-1H-furo[2,3-c]pyrazol-4(5H)-ylidene]-1H-benzimidazol-2-amine (7) and 2-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-4H-furo [3,2-c]chromen-4-one (13) were found to exhibit the most potent in vitro antifungal activity with MICs (6.25 mu g/mL) against B. fabae and F. oxysporum. (C) 2011 Elsevier Masson SAS. All rights reserved.”
“Classical risk assessment models for setting safe occupational exposure limits (OEL) have used multiple uncertainty factors (UF) applied to a point of departure (POD), e.g., a No Observed Effect Level (NOEL), which in some cases is the pharmacological effect. Dapagliflozin promotes glucosuria by inhibiting the renal sodium-glucose cotransporter-2 transporter. The initial OEL for dapagliflozin (0.002 mg/m(3)) was calculated when low dose clinical data was not available to identify a NOEL resulting in the need to use excessive UFs. To reduce the UFs from the OEL, a clinical pharmacodynamic [glucosuria and urinary glucose dipstick (UGD)] and pharmacokinetic study was conducted with single oral doses of 0.001, 0.01, 0.1, 0.3, 1.0 or 2.

33 Mb deletion of 1q21.3q23.3 (hg18; chr1: 153035245-159367106) in two siblings presenting with blepharophimosis, ptosis, microbrachycephaly, severe psychomotor, and intellectual disability. Additional common features include small corpus callosum, normal birth length and head circumference, postnatal growth restriction, low anterior hairline, upturned nose, bilateral preauricular pits, widely spaced teeth, gingival hypertrophy, left ventricular dilatation with decreased biventricular systolic function, delayed bone age, 5th finger clinodactyly, short 3rd digit, hyperconvex

nails, obstructive and central sleep apnea, and bilateral heel contractures. Fluorescence in situ hybridization (FISH) performed in the mother of both children ASP2215 purchase showed an apparently balanced, intrachromosomal insertional translocation of 1q21.3q23.3 to 1q42.12. Doramapimod The sibling recurrence likely arose by a maternal meiotic crossing over on the rearranged chromosome 1 between the deleted region

and the insertion. We hypothesize that the decreased cardiac function and contractures may be related to LMNA haploinsufficiency. This case illustrates the importance of FISH when attempting to determine inheritance of a copy-number variation and emphasize the value of evaluating known haploinsufficiency phenotypes for genes in deleted regions. (C) 2012 Wiley Periodicals, Inc.”
“We found that the epigallocatechin gallate (EGCG)/epigallocatechin (EGC) ratio in a green tea (Camellia sinensis L.) extract was affected by the extraction temperature.

The EGCG/EGC ratio in the 4 degrees C extract was around 1:3-4, whereas selleck chemicals llc in the 100 degrees C extract, it was around 1:0.7. Oral administration of the mixture with a high EGC ratio (1:2-3 = EGCG/EGC) resulted in greater IgA production by murine Peyer’s patch cells.”
“Introduction: Group sex among gay men has been associated with other HIV risk behaviours. Gay men who engage in group sex may be at increased risk of infection with HIV and other sexually transmitted infections (STI).\n\nMethods: The Three or More Study (TOMS) of group sex among gay men utilised an anonymous, self-completed survey about participants’ most recent occasion of group sex with other men and in-depth interviews with a small number of these survey participants. The 436 men who reported having engaged in group sex within the previous month were included in these analyses.\n\nResults: Among 436 men who engaged in group sex within the previous month, 32.5% reported unprotected anal intercourse (UAI) with non-regular, mostly HIV non-seroconcordant partners at this recent group sex encounter (GSE) and the majority reported other sex practices that are risk factors for STI other than HIV. Over one-third reported having been tested for HIV or other STI since their last GSE; those who had engaged in UAI at the GSE were more likely to have been tested (p = 0.008).